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Binding of transcription factors measured on individual DNA molecules in living cells. An important question in the field of gene regulation is how a limited set of transcription factors interpret the same genome in different ways to create over cell types found in our bodies, all of which are defined by the expression of a unique set of genes. To achieve this, transcription factors have evolved cooperative mechanisms to enable precise control of gene expression. In a new study, members of the Krebs group in the Genome Biology Unit at EMBL Heidelberg have developed a method to directly visualise how transcription factors co-occupy DNA in living cells, and have used it to better understand their cooperativity mechanisms. Transcription factors are proteins that bind to specific regulatory DNA sequences to control which genes are turned on or off.
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A British man flew home from Marrakech last week after being jailed for "homosexual acts". There was a time though when Morocco was renowned as a haven for gay Americans and Britons, who fled restrictions in their own countries to take advantage of its relaxed atmosphere. Take a walk down one of the main streets in Tangier, the Boulevard Pasteur, turn left before the Hotel Rembrandt and descend towards the sea. Then follow some steps into a narrow side street that smells of urine and screams of danger. Overlooking an empty space that looks like a disused car park or the aftermath of a nuclear bomb, is a family-run hostel called El Muniria, a white block with blue windowsills and a crenelated roof. It was here in Room 9, in the s, that William Burroughs, high on drugs, wrote one of the 20th Century's most shocking novels, Naked Lunch. The book, banned under US obscenity laws, is a mixture of autobiography, science fiction and satire, peppered with descriptions of gay sex.
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